Beta-Catenin

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β-Catenin is involved in cell adhesion through catenin-cadherin complexes and in the Wnt signaling pathway. Deregulation allows β-Catenin to accumulate in the nucleus, which may be useful in aiding the differential diagnosis of selected neoplasms. β-Catenin adhesion complex impairment is also associated with a poorly differentiated phenotype and increased invasiveness of carcinomas. Cytoplasmic localization of β-Catenin has been demonstrated as a marker of poor outcome in breast cancer patients. Studies suggest it may be useful in the differential diagnosis of selected soft tissue tumors and tumors of the GI tract, pancreas, lung, and female genital tract.

Intended Use

IVD

Source

Mouse Monoclonal

Clone

14

Species Reactivity

Human

Isotype

IgG1

Antigen

Mouse ß-Catenin aa. 571-781

Localization

Cytoplasm, Membrane & Nucleus

1. Bukholm IK, Nesland JM, Børresen-Dale AL. J Pathol. 2000 Jan; 190(1):15-9.
2. Montgomery E, Folpe AL. Adv Anat Pathol. 2005 Nov; 12(6):350-6.
3. Kikuchi, A. Biochem Biophys Res Commun. 2000 Feb; 268(2):243-8.
4. Blӓker H, et al. Genes Chromosomes Cancer. 1999 Aug; 25(4):399-402.
5. Burford H, et al. Am J Clin Pathol. 2009 Dec; 132(6):831-9.

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