Bcl-6 [LN22]

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BCL-6 Mouse Monoclonal Antibody is commonly expressed in diffuse large cell lymphomas, follicular lymphomas and Burkitt’s lymphoma/leukemia. Bcl-6 protein is expressed mainly by follicle center cells, a few interfollicular T lymphocytes and in nodular lymphocyte predominant Hodgkin’s disease. However Blc-6 mouse monoclonal is not expressed in hairy cell leukemia, mantle cell or marginal-zone derived lymphomas. In humans, Bcl-6 encodes for a Kruppel-type zinc finger protein that is believed to be important in germinal center formation. The LN22 clone of Bcl-6 provides superior sensitivity compared to [PIF6].

The Bcl-6 gene, originally cloned from a tumor with 3q27 translocation, is commonly expressed in large cell lymphomas. In humans, Bcl-6 encodes for a Kruppel-type zinc finger protein that is believed to be important in germinal center formation.

Intended Use

IVD

Source

Mouse Monoclonal

Clone

LN22

Isotype

IgG2b

Antigen

AA 1-350 N-terminus human Bcl-6 oncoprotein

Localization

Nuclear

Positive Control

Tonsil or Follicular Lymphoma

Antibody Download
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1. Pillai RK, et al. Am J Surg Pathol. 2013 Mar; 37(3):323-32.
2. Hoefnagel JJ, et al. Br J Dermatol. 2003 Dec; 149(6):1183-91.
3. Dunphy CH, et al. Leuk Lymphoma. 2001 May; 41(5-6):585-92.
4. Dogan A, et al. Am J Surg Pathol. 2000 Jun; 24(6):846-52.
5. Yang B, et al. Am J Surg Pathol. 2000 May; 24(5):694-702.

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