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Amyloidosis is a heterogeneous group of disorders characterized by extracellular deposition of abnormal protein fibrils, which are derived from different proteins. The Amyloid A Antibody reacts with native and fixed amyloid fibrils. The Antibody also reacts with amyloid deposits in many tissues including kidney and rectum. Cross-reactivity with serum precursor of protein AA has been observed. The application of Congo Red, Amyloid A and Amyloid P in tissues with amyloid deposits has been shown to be superior to Congo Red alone.
Amyloid deposits in kidney, or other amyloid-infiltrated tissue
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1. Linke RP. Prog Histochem Cytochem. 2012 Aug; 47(2):61-132. 2. Linke RP, Gӓrtner HV, Michels H. J Histochem Cytochem. 1995 Sep; 43(9):863-9. 3. Linke RP. J Histochem Cytochem. 1984 Mar; 32(3):322-8.