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AMACR (RM), 3X is being discontinued. We will continue to offer these products until 06/30/16 or until current inventory is depleted, whichever occurs first. Biocare does offer AMACR (RM) or AMACR (RM), 2X, catalog numbers APA3024, OAA3024 or APA3016 as a substitute.
α-Methylacyl coenzyme A racemase (AMACR Antibody), also known as P504S, is a peroxisomal and mitochondrial enzyme that plays a role in bile acid synthesis and β-oxidation of branched chain fatty acids. In immunohistochemistry, AMACR Antibody has been shown to be a specific marker of prostatic adenocarcinoma. Additionally, prostate glands involved in PIN have been found to express AMACR, whereas AMACR was nearly undetectable in benign glands. AMACR + CK5/14 may be used to assess neoplasia in prostate biopsies. AMACR Antibody stains the majority of prostate cancer; however, AMACR has been shown to stain many other types of carcinomas such as hepatomas, breast carcinomas, pancreatic and islet tumors.
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Regulatory Notice: Biocare’s IVD-labeled products comply with US-FDA and European IVDD regulation. Other regions may have additional requirements for such labeling, please contact your local distributor.
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3. Rubin MA, et al. α-Methylacyl Coenzyme A Racemase as a Tissue Biomarker for Prostate Cancer. JAMA 2002; 287:1662-1670.
4. Luo J, et al. Alpha-methylacyl-CoA racemase: a new molecular marker for prostate cancer. Cancer Res 2002; 62:2220-2226.
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6. Wu CL, et al. Analysis of α-Methylacyl-CoA Racemase (P504S) Expression in High-Grade Prostatic Intraepithelial Neoplasia. Hum Pathol 2004; 35:1008-1013.
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