Alpha-1-Fetoprotein (AFP)

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This antibody reacts with human Alpha-1-Fetoprotein (AFP). Alpha-1-Fetoprotein antibody reacts with germ-cell tumors, gonadal tumors and liver carcinoma. Neoplasms commonly associated with Alpha-1-Fetoprotein (AFP) production are hepatocellular carcinomas and some germ cell tumors, typically yolk sac tumor. Rare tumors of visceral origin may also be associated with Alpha-1-Fetoprotein (AFP) production. Studies show that in hepatocellular carcinoma, Alpha-1-Fetoprotein (AFP) expression usually indicates malignancy in a hepatocellular nodule and hepatocytic histogenesis of a malignancy. Traces of contaminating antibodies have been removed by solid-phase absorption with human plasma proteins.

Source

Rabbit Polyclonal

Species Reactivity

Human

Clone

N/A

Isotype

N/A

Antigen

AFP

Localization

Cytoplasmic

Positive Control

Hepatocytes of fetal liver or hepatoma

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1. Caruso RA. Hepatoid gastric adenocarcinoma. A histological and immunohistochemical study of a case. Eur J Basic Appl Histochem 1991;35(2):203 -209.
2. Scheithauer W, Chott A, Knoflach P. Alpha-fetoprotein-positive adenocarcinoma of the pancreas. Int J Pancreatol 1989 Feb;4(1):99-103.
3. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
4. National Committee for Clinical Laboratory Standards (NCCLS). Protection of laboratory workers from infectious diseases transmitted by blood and tissue; proposed guideline. Villanova, PA 1991;7(9). Order code M29-P.

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