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Chromosome 6q deletions are also commonly found in lymphoid malignancies such as acute lymphocytic leukemia (ALL), approx 30% of cases1; chronic lymphocytic leukemia (CLL), non-Hodgkins lymphoma (NHL), approx 7%, multiple myeloma (MM), mantle zone lymphoma (MZL), and Waldenström’s macroglobulinemia (WM)2.
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1. 6q Deletions in Acute Lymphoblastic Leukemia and Non-Hodgkin’s Lymphomas. Mats Merup, Teresa Calero Moreno, Mats Heyman, Kristina Rönnberg, et al. Blood, Vol 91, No 9 (May 1), 1998: pp 3397-3400
2. Sinclair PB, Sorour A, Martineau M, Harrison CJ, Mitchell WA, O’Neill,E, Foroni L. A fluorescence in situ hybridization map of 6q deletions in acute lymphocytic leukemia: identification and analysis of a candidate tumor suppressor gene. Cancer Res. 2004;64:4089-4098.
3. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory workers from occupationally Acquired Infections; Approved Guideline-Fourth Edition CLSI document M29-A4 Wayne, PA 2014.