PHOSPHO-EGFR
Epidermal Growth Factor Receptor (EGFR) is a 170kDa transmembrane glycoprotein receptor tyrosine kinase and is activated by EGF. This activation affects cell growth and differentiation. The carboxy terminal tyrosine residues on EGFR, Tyr1068, Tyr1148 and Tyr1173, are major sites of autophosphorylation, which occurs as the result of EGF binding. Once activated, phosphotyrosines mediate the binding of growth factor receptor-binding protein-2 (Grb2) to the EGFR. This antibody only detects EGFR phosphorylated on Tyrosine 1068 of the mature human isoform that corresponds to Y1092 from the precursor form P00533-1(p170). Over-expression of EGFR has been reported in tumors of breast, lung, colon, cervix, ovary, esophagus and endometrium.
| Ordering Information |
Catalog Number |
Volume |
| Concentrate |
N/A |
N/A |
| Predilute |
PME 300 |
AA |
| intelliPATH™ |
N/A |
N/A |
| VP Echelon |
N/A |
N/A |
| A / AK = 0.1 ml |
B / BK = 0.5 ml |
C / CK = 1.0 ml |
G5 = 5.0 ml |
AA = 6.0 ml |
H / G25 = 25 ml |
L = 100 ml |
