c-Myc
The oncogene-encoded protein c-Myc is a transcription factor localized to the nucleus of the cell. c-Myc is postulated to play a role in activating the transcription of growth related genes, thereby influencing cell proliferation, differentiation, apoptosis, and cell cycle progression.
Amplification of the c-Myc gene has been found in several types of human tumors. Studies have shown that c-Myc is essential for vasculogenesis and angiogenesis in neoplastic disease.
c-Myc oncogene activity may also be necessary for the translocation(s) seen in human breast tumors identified to have a poor-prognosis signature and metastasis to distant sites. Over-expression of the c-Myc oncogene has been implicated in the development and progression of human prostate carcinoma.
| Specifications | |
|---|---|
| Intended Use | IVD |
| Source | Rabbit Monoclonal |
| Species Reactivity | Human, Others not tested |
| Clone | Y69 |
| Isotype | Rabbit IgG |
| Antigen | Synthetic peptide corresponding to residues in N-terminus of human c-Myc |
| Cellular Localization | Nucleus |
| Positive Control | Breast Cancer, Some prostate |
| Normal Tissue | Skin |
| Abnormal Tissue | Breast Cancer, Some prostate |
| Ordering Information | Catalog Number | Volume |
|---|---|---|
| Concentrate | CME 415 | AK, CK |
| Predilute | PME 415 | AA |
| intelliPATH™ | N/A | N/A |
| VP Echelon | N/A | N/A |
| A / AK = 0.1 ml | B / BK = 0.5 ml | C / CK = 1.0 ml | G5 = 5.0 ml | AA = 6.0 ml | H / G25 = 25 ml | L = 100 ml |
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| Data Sheets |
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| Download Data Sheet |
