Cytokeratin 5 (CK5)
CK5 is a type II intermediate filament protein that is expressed in active basal layers of most stratified squamous epithelia. Studies have shown CK5/6 to be a specific marker for lung squamous carcinoma and mostly negative for lung adenocarcinoma. In a published study, rabbit monoclonal CK5 antibody was compared to mouse monoclonal CK5/6. CK5 was 84% sensitive and 100% specific for lung SqCC when compared to CK5/6 (80% sensitivity and 97% specificity). CK6 mRNA has been detected in lung adenocarcinomas and thus CK5 alone, may be a more specific marker than CK5/6. This predilute has been optimized for lung squamous cell carcinoma; other tumors have not been tested.
*Part of the PulmoPanel™ Kit for diagnosing lung cancer, to order use Cat. No. PPM 435 AAK.
The PulmoPanel™ Kit includes: CK5, Desmoglein 3, Napsin A, p63, TRIM29 and TTF-1.
| Ordering Information |
Catalog Number |
Volume |
| Concentrate |
CME 430 |
A, B |
| Predilute |
PME 430 |
AA |
| intelliPATH™ |
N/A |
N/A |
| VP Echelon |
N/A |
N/A |
| A / AK = 0.1 ml |
B / BK = 0.5 ml |
C / CK = 1.0 ml |
G5 = 5.0 ml |
AA = 6.0 ml |
H / G25 = 25 ml |
L = 100 ml |
