Biocare Expands Antibody Choices for Ventana Instruments

Enhancing the VP Echelon product line, Biocare is pleased to announce the addition of p40 mouse monoclonal, Arginase-1, and Uroplakin II to our menu of prediluted antibodies optimized for the Ventana® BenchMark® XT Immunohistochemistry Staining Systems.

The mouse monoclonal antibody p40 [BC28] may have applications in cases where p63 is used. While p63 has proven to be a sensitive marker for lung SqCC, it suffers from specificity limitations due to reactivity in a subset of lung adenocarcinomas. In contrast, p40 is selectively expressed in lung SqCC. p40 (M) [BC28] was found to be a sensitive marker in other neoplastic tissues, including bladder, prostate, breast, and head and neck cancers.

The Arginase-1 (ARG-1) rabbit monoclonal antibody is a highly specific and sensitive marker of hepatocellular carcinoma (HCC). In an in-house study, ARG-1 rabbit monoclonal demonstrated higher sensitivity than the polyclonal and HepPar-1 for all grades of HCC. ARG-1 [EPR 6672B] is very specific, as it does not stain pancreatic tumors and shows limited staining in normal tissues except liver, pancreas, and kidney. ARG-1 provides a more sensitive and specific diagnostic marker delineating primary HCC from tumors metastatic to the liver.

Uroplakin II [BC21] mouse monoclonal is a highly specific antibody that may be useful in identifying tumors of urothelial origin. In cases of urothelial carcinoma of the bladder, [BC21] exhibits increased sensitivity (78%, 46/59) when compared to Uroplakin III [AU1] (34%, 19/56). With the exception of bladder and ureter, Uroplakin II [BC21] was found to be 100% specific when evaluated in various normal and neoplastic tissues, including prostate cancer and renal cell carcinoma. PATENT PENDING.

The VP Echelon line is a collection of optimized and prediluted antibodies that have been tested on the Ventana® Benchmark® XT Immunohistochemistry Staining System. These conveniently packaged reagents are ready for loading into reagent dispensers supplied by Ventana. These antibodies have been titered and quality controlled to assure consistent performance and high quality staining. Biocare provides ready-to-use antibodies in 6.0 ml (60 tests) and 25 ml (250 tests) formats. The product line also includes V-Blocker (universal protein blocking reagent) and Monet Antibody Diluent (only for use with concentrated primary antibodies).
For more information, please visit: http://biocare.net/products/vp-antibodies/.

About Biocare Medical, LLC
Biocare Medical, LLC is an innovator in developing and supplying world class automated immunohistochemistry (IHC) instrumentation, and the full range of reagents for IHC lab testing. Biocare Medical is the market leader in simultaneous Multiplex IHC and antibody development, which aids in the assessment of clinical cases and accelerates turnaround time. The company’s customers include clinical histology laboratories, pharmaceutical companies, CROs, and biotechnology companies as well as academic, government, military, and other non-profit laboratories. Biocare Medical offers an expanding portfolio of integrated products to address the rapidly growing cancer and infectious disease diagnostic and research markets using tissue immunostaining and in situ hybridization methods. Biocare Medical is headquartered and has manufacturing facilities in Concord, California, and has a global distribution network. For more information, please visit www.biocare.net.

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