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Lab Services Available for IHC, IF, ISH & FISH
IHC – immunohistochemistry
CAP/CLIA accredited facility with capabilities spanning frozen and FFPE sections; Biocare can accommodate ‘on demand’ custom work on other samples types. Sections can be provided directly by the researcher or cut in our lab. IHC assay optimization including development of antibody cocktails to facilitate multiplex staining. Micro-polymer based detection chemistries with high sensitivity and specificity optimized for a variety of species including human, monkey, rodent, rabbit, dog and cat.
ISH – in situ hybridization
Optimization of ISH assay conditions using your probe or custom Biocare design to your desired target. Complete assay development, implementation and training in your laboratory. Multiplex IHC and ISH assay feasibility and optimization. Combination gene and protein expression assays utilizing simultaneous multiplexing on a single slide.
Probe design, assay optimization and FISH staining on FFPE, blood and cytological fluids. Patent-pending DelTECT™ multicolor platform for deletion detection improves accuracy by reducing false positive deletion readouts due to truncation artifacts. Improved labeling technology and use of CGH and Patient Cohort data results in ‘tight and bright’ probes designed to reduce both false negatives and false positives. Samples can be sent as FFPE blocks, blood films or cytological preparations of body fluids including urine.
ANTIBODY & PROTEIN LABELING
Fluorescent labeling of primary antibodies utilizing a variety of different wavelength fluors and linker chemistries. Small volume feasibility lots to large volume batches for routine testing. RUO, IUO and IVD manufacture under GMP conditions.
Screening of multiple clones of research antibody to determine optimum titer or target tissue. Sensitivity and specificity testing on multiple tissue and tumor types. Testing of a variety of antibody conditions to meet project requirements. Testing from multiple hostspecies, including rabbit, rodent, human.