Uro-2™ (CK20 + p53)

(L) Bladder CIS & (R) Reactive atypia in bladder stained with Uro-2™

Uro-2™ (CK20 + p53) can be used to differentiate urothelial reactive atypia from CIS (carcinoma in situ) in bladders. In normal urothelium, the superficial umbrella cell layer shows reactivity for CK20 only; whereas, p53 nuclear staining is absent to focal. For urothelium with reactive atypia, particularly in cases with marked atypia, CK20 and p53 staining remain identical to those seen in normal urothelium. In cases of CIS, diffuse, strong cytoplasmic reactivity for CK20 and diffuse nuclear reactivity for p53 is observed throughout the urothelium. Most high-grade dysplasia stains with p53 when compared to low-grade dysplasia, which may aid the pathologist in differentiating between high and low grade dysplasia in bladder urothelium.

Optional CD44 for use with Uro-2™:

Reactive atypia in bladder stained with CD44 [Bajoran Purple Chromogen].
Reactive atypia stained with CD44 (PM380) [purple].

Specifications  
Intended Use
Source ,
Species Reactivity ,
Clone ,
Isotype
Antigen
Cellular Localization ,
Positive Control ,
Normal Tissue
Abnormal Tissue ,
Ordering Information Catalog Number Volume
Concentrate N/A N/A
Predilute API 3001DS AA
intelliPATH™ N/A N/A
VP Echelon N/A N/A
A / AK = 0.1 ml B / BK = 0.5 ml C / CK = 1.0 ml G5 = 5.0 ml AA = 6.0 ml H / G25 = 25 ml L = 100 ml
Data Sheets
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