S100 Protein Cocktail
The S100 cocktail recognizes proteins of 21-24kDa, identified as A and B subunits of S100 protein. S100 belongs to the family of calcium binding proteins such as calmodulin and troponin C. S100A is composed of alpha and beta chains whereas S100B is composed of two beta chains. Antibody S100 stains melanocytes, schwannomas, peripheral neural tissue, astrocytes, benign and malignant melanomas, and their metastases. S100 protein is also expressed in the antigen presenting cells such as the Langerhans cells in skin and interdigitating reticulum cells in the paracortex of lymph nodes. Histocytosis X can also be confirmed by S100 staining. The S100 monoclonal cocktail is potentially more sensitive than other S100 single clone antibodies; and thus is an excellent pan-melanoma marker. S100 protein is highly soluble and may be eluted from frozen tissue during staining.
| Ordering Information |
Catalog Number |
Volume |
| Concentrate |
CM 089 |
A, B, C |
| Predilute |
PM 089 |
AA, H |
| intelliPATH™ |
IP 089 |
G10, G20 |
| VP Echelon |
N/A |
N/A |
| A / AK = 0.1 ml |
B / BK = 0.5 ml |
C / CK = 1.0 ml |
G5 = 5.0 ml |
AA = 6.0 ml |
H / G25 = 25 ml |
L = 100 ml |
