Prostate Specific Antigen Cocktail
Recognizes a single protein of 33-34kDa, identified as the prostate specific antigen (PSA). PSA cocktail is made with clones ER-PR8 and A67-B/E3 whose epitopes are not precisely mapped, but the experimental data suggest that they are different. The cocktail is highly specific to PSA and stains prostatic secretory and ductal epithelium in both normal and neoplastic tissues. PSA is a chymotrypsin-like serine protease (kallikrein family) exclusively produced by the prostate epithelium, and abundant in seminal fluid. PSA can be detected in the sera of patients with prostatic carcinoma. It is predominantly complexed to a liver-derived serine protease inhibitor, alpha-1 antichymotrypsin (AACT). A higher proportion of serum PSA is complexed to AACT in prostate cancer than in benign prostate hyperplasia. Biocare’s cocktail is extremely sensitive in detecting PSA to identify neoplasms of prostatic origin.
| Ordering Information |
Catalog Number |
Volume |
| Concentrate |
CM 019 |
A, C |
| Predilute |
PM 019 |
AA |
| intelliPATH™ |
IP 019 |
G10 |
| VP Echelon |
N/A |
N/A |
| A / AK = 0.1 ml |
B / BK = 0.5 ml |
C / CK = 1.0 ml |
G5 = 5.0 ml |
AA = 6.0 ml |
H / G25 = 25 ml |
L = 100 ml |
