BC8

CD44

Breast cancer stained with CD44 antibody

CD44 antigen is a transmembranous glycoprotein (80 kDa) antibody that is specific for epitope 3 of the CD44 H molecule, CD44 (HCAM) is a cell adhesion molecule that plays an important role in the cascade of metastasis and progression of human malignant tumours. CD44 antigen is present on T lymphocytes, granulocytes, red blood cells, brain and epithelial cells. The standard isoform, CD44s, are also expressed in a wide range of normal tissures such as tonsil, skin, bladder and cervical squamous epithelium. In breast cancer studies, CD44 expression, as assessed by immunohistochemical staining demonstrated a favorable prognostic factor in patients with node-negative invasive breast carcinoma, Further studies have shown a subpopulation of CD44+/CD24- in breast cancer cells have stem/progenitor cell properties.

The CD44 predilute (PM 380) is tittered specifically for use in bladder cancer (see image below). It may be used an optional step with the Uro-2™ (CK20 + p53) Multiplex Cocktail (API 3001DS).

Reactive atypia in bladder stained with CD44 [Bajoran Purple Chromogen].
Reactive atypia in bladder stained with CD44 [Bajoran Purple Chromogen].

Specifications  
Intended Use
Source
Species Reactivity ,
Clone
Isotype
Antigen
Cellular Localization ,
Positive Control ,
Normal Tissue
Abnormal Tissue ,
Ordering Information Catalog Number Volume
Concentrate CM 380 B
Predilute PM 380 AA
intelliPATH™ N/A N/A
VP Echelon N/A N/A
A / AK = 0.1 ml B / BK = 0.5 ml C / CK = 1.0 ml G5 = 5.0 ml AA = 6.0 ml H / G25 = 25 ml L = 100 ml
Data Sheets
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