TTF-1
Thyroid transcription factor-1 (TTF-1) is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate and adrenal glands are not reactive. TTF-1 is detected in primary lung adenocarcinomas and small cell carcinomas. It is absent in mesotheliomas, colon cancer and breast cancer. TTF-1 can be very useful when used in a panel with CK7, CK20, Villin and CA125 antibodies.
*Part of the PulmoPanel™ Kit for diagnosing lung cancer, to order use Cat. No. PPM 435 AAK.
The PulmoPanel™ Kit includes: CK5, Desmoglein 3, Napsin A, p63, TRIM29 and TTF-1.
| Specifications | |
|---|---|
| Intended Use | IVD |
| Source | Mouse Monoclonal |
| Species Reactivity | Human, Others not tested |
| Clone | 8G7G3/1 |
| Isotype | IgG1 |
| Antigen | TTF-1 |
| Cellular Localization | Nuclear |
| Positive Control | Lung adenocarcinoma, Thyroid |
| Normal Tissue | Lung, Thyroid |
| Abnormal Tissue | Lung adenocarcinomas |
| Ordering Information | Catalog Number | Volume |
|---|---|---|
| Concentrate | CM 087 | A, B, C |
| Predilute | PM 087 | AA |
| intelliPATH™ | IP 087 | G10 |
| VP Echelon | VP 087 | G |
| A / AK = 0.1 ml | B / BK = 0.5 ml | C / CK = 1.0 ml | G5 = 5.0 ml | AA = 6.0 ml | H / G25 = 25 ml | L = 100 ml |
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