PU.1
PU.1 is a 40-42kDa protein and is an Ets-family transcription factor, which regulates the expression of immunoglobulin and other genes that are important for B-cell development. It is expressed in B-lymphocytes and macrophages. PU.1 also appears to be critically involved in the control of monocyte development by regulation of the expression of the macrophage colony-stimulating factor receptor. Results have shown a lack of PU.1 expression by neoplastic cells in classic Hodgkin’s disease (cHD), but not in lymphocyte predominant HD. The lack of PU.1 protein expression in cHD likely contributes to the lack of immunoglobulin expression and incomplete B-cell phenotype characteristic of the Reed-Sternberg cells in cHD. Therefore, PU.1 may represent a useful reagent for the interpretation of lymphocyte-predominant Hodgkin’s disease.
| Ordering Information |
Catalog Number |
Volume |
| Concentrate |
CM 309 |
AK |
| Predilute |
N/A |
N/A |
| intelliPATH™ |
N/A |
N/A |
| VP Echelon |
N/A |
N/A |
| A / AK = 0.1 ml |
B / BK = 0.5 ml |
C / CK = 1.0 ml |
G5 = 5.0 ml |
AA = 6.0 ml |
H / G25 = 25 ml |
L = 100 ml |
