CD79a
CD79a is an intracellular component of the signal transduction pathway of the B-cell Receptor (BCR). CD79a first appears at pre-B-cell stage, early in maturation. It persists until the plasma cell stage, when it is found as an intracellular component. CD79a is found in the majority of acute leukemias of precursor-B-cell type. It is also found in B-cell lines, B-cell lymphomas, and in some myelomas. It is not present in myeloid or T-cell lines. In a study by Mason, et al (Blood, 1995) on a total of 454 paraffin-embedded tissues, it reacted with 97% of B-cell neoplasms. This antibody labels precursor B-cell acute lymphoblastic leukemia samples, making it the most reliable B-cell marker for this disorder. It is therefore highly recommended that CD79a be used in conjunction with CD20 [L26] for the identification of B-cell neoplasms. CD79a for B-cell is conserved across many species. Therefore, this antibody may be useful in the identification of lymphocyte subsets in species other than human.
| Ordering Information |
Catalog Number |
Volume |
| Concentrate |
CM 067 |
A, C |
| Predilute |
PM 067 |
AA |
| intelliPATH™ |
N/A |
N/A |
| VP Echelon |
N/A |
N/A |
| A / AK = 0.1 ml |
B / BK = 0.5 ml |
C / CK = 1.0 ml |
G5 = 5.0 ml |
AA = 6.0 ml |
H / G25 = 25 ml |
L = 100 ml |
