Bcl-2
BIOCARE’s 100/D5 MAb is highly specific to bcl-2(alpha) and shows no crossreaction with bcl-x or bax protein. Bcl-2 (b-cell lymphoma #2) is a proto-oncogene at 18q21.3; encodes 25 kDa protein mainly localized to inner mitochondrial membrane; also endoplasmic reticulum and nuclear envelope. Expression of bcl-2 alpha oncoprotein has been shown to inhibit the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of bcl-2 protein, whereas the normal or hyperplastic germinal centers are negative.
| Ordering Information |
Catalog Number |
Volume |
| Concentrate |
CM 003 |
A, C |
| Predilute |
PM 003 |
AA |
| intelliPATH™ |
N/A |
N/A |
| VP Echelon |
N/A |
N/A |
| A / AK = 0.1 ml |
B / BK = 0.5 ml |
C / CK = 1.0 ml |
G5 = 5.0 ml |
AA = 6.0 ml |
H / G25 = 25 ml |
L = 100 ml |
