ALKc
ALK recognizes the formalin-resistant epitope of native anaplastic lymphoma kinase (ALK) protein. ALK recognizes a 200 kDa transmembrane molecule expressed only in neural tissues. The ALKc reacts with normal ALK protein, as well as with the chimeric protein ALK-NPM. ALKc specifically labels t(2,5)-positive cells giving strong cytoplasmic staining that is also associated with nuclear staining. Anaplastic large cell lymphoma (ALCL) is a heterogeneous group of diseases by morphology, immunophenotyping and clinical presentation. It can be difficult to diagnose because of it’s similarity to Hodgkin’s. However, treatment and prognosis of Hodgkin’s and ALCL is very different, and it is imperative to diagnose correctly. Research has shown that ALKc stains the majority of CD30+ ALCL. It has not been shown to stain Hodgkin’s disease (Reed-Sternberg cells). AlKc should be used in a panel with CD15, CD30, TIA-1 and EMA. ALKc has been shown to stain more intense than ALK1.
| Ordering Information |
Catalog Number |
Volume |
| Concentrate |
CM 051 |
A, C |
| Predilute |
PM 051 |
AA |
| intelliPATH™ |
IP 051 |
G10 |
| VP Echelon |
N/A |
N/A |
| A / AK = 0.1 ml |
B / BK = 0.5 ml |
C / CK = 1.0 ml |
G5 = 5.0 ml |
AA = 6.0 ml |
H / G25 = 25 ml |
L = 100 ml |
