SALL4
SALL4, a newly identified zinc-finger transcriptional factor, is required for the maintenance of embryonic stem cell pluripotency by modulating Oct4, and is mapped to chromosome 20q13. SALL4 is a novel sensitive and specific marker for seminomas and ovarian primitive germ-cell tumors. Studies demonstrate that over 90% of tumor cells in intratubular germ-cell neoplasias and embryonal carcinomas show strong SALL4 staining. In one study, 100 percent of all 31 yolk sac tumors (5 pediatric and 26 postpubertal) showed strong positive SALL4 staining of tumor cells, but were negative for Oct4. This marker is particularly useful in distinguishing yolk sac tumors from clear cell carcinomas. SALL4 is a promising new pan germ-cell marker and has been shown to be superior to PLAP and Oct4 antibodies.
| Ordering Information |
Catalog Number |
Volume |
| Concentrate |
CM 384 |
A, C |
| Predilute |
PM 384 |
AA |
| intelliPATH™ |
IP 384 |
G10 |
| VP Echelon |
N/A |
N/A |
| A / AK = 0.1 ml |
B / BK = 0.5 ml |
C / CK = 1.0 ml |
G5 = 5.0 ml |
AA = 6.0 ml |
H / G25 = 25 ml |
L = 100 ml |
