Bcl-6 Description
The Bcl-6 gene, originally cloned from a tumor with 3q27 translocation, is commonly expressed in large cell lymphomas. In humans, bcl-6 encodes for a Kruppel-type zinc finger protein and is believed to be important in germinal center formation. Bcl-6 protein is expressed mainly by follicle center cells and in a few interfollicular T- lymphocytes. Bcl-6 has also been detected in Burkitts lymphoma and in nodular, lymphocyte predominant Hodgkins disease. Bcl-6 is not expressed in hairy cell leukemia, mantle cell or marginal-zone derived lymphomas. Reactivity shows strong nuclear staining.