| ANTIBODY PHOTO | CD3 (M) | |
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CD3 (M) Description Monoclonal antibody to human CD3, when used in conjunction with other antibodies, is regarded as a reliable pan T-cell antibody used in the immunophenotyping of lymphomas in paraffin sections. Most T-cell lymphomas show positivity for CD3. Notable exceptions include some of the more aggressive large T-cell lymphomas and anaplastic large cell (Ki-1, CD30) lymphomas, which may not express detectable antigen. CD3 immunoreactivity has also been reported in a minority of Reed-Sternberg cells of Hodgkins disease and in some histiocytic tumors. CD3 expression of hemapoietic cells of the lymphoid, myeloid, and erythroid lineages in the human fetal and embryonic liver is rare. In a study of 50 archived T-cell lymphomas (Cabecadas et al) UCHL-1 (a monoclonal antibody to CD45RO) showed reactivity with 94% of cases, but lacked absolute specificity for T-cells, especially in high-grade lymphomas. CD3 showed reactivity with 80% of neoplastic cells, but with a higher specificity. Used in conjunction, UCHL-1 and monoclonal CD3 identified the majority of T-cell lymphomas in paraffin sections. |
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| PHOTO DESC. | Cat No. | |
| Tonsil stained with CD3 antibody. | intelliPATH FLX | IP 110 G10, G20 |
| CONCENTRATE | CM 110 AK, BK, CK | |
| PREDILUTE | PM 110 AA | |
| CLONE | PS1 | |
| DOWNLOADS | SOURCE | Mouse monoclonal |
| ISOTYPE | IgG2a | |
| ANTIGEN | CD3 | |
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