| ANTIBODY PHOTO | ALKc | |
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ALKc Description ALK recognizes the formalin-resistant epitope of native anaplastic lymphoma kinase (ALK) protein. ALK recognizes a 200 kDa transmembrane molecule expressed only in neural tissues. The ALKc reacts with normal ALK protein, as well as with the chimeric protein ALK-NPM. ALKc specifically labels t(2,5)-positive cells giving strong cytoplasmic staining that is also associated with nuclear staining. Anaplastic large cell lymphoma (ALCL) is a heterogeneous group of diseases by morphology, immunophenotyping and clinical presentation. It can be difficult to diagnose because of its similarity to Hodgkins. However, treatment and prognosis of Hodgkins and ALCL is very different, and it is imperative to diagnose correctly. Research has shown that ALKc stains the majority of CD30+ ALCL. It has not been shown to stain Hodgkins disease (Reed-Sternberg cells). AlKc should be used in a panel with CD15, CD30, TIA-1 and EMA. ALKc has been shown to stain more intense than ALK1. |
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| PHOTO DESC. | Cat No. | |
| Anaplastic large cell lymphoma stained with ALKc antibody. | intelliPATH FLX | IP 051 G10 |
| CONCENTRATE | CM 051 A, B, C | |
| PREDILUTE | PM 051 AA | |
| CLONE | ALKc | |
| DOWNLOADS | SOURCE | Mouse monoclonal |
| ISOTYPE | IgG1 | |
| ANTIGEN | ALK (Anaplastic lymphoma kinase) | |
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