| ANTIBODY PHOTO | CD30 (Ki-1) [Ber-H2] | |
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CD30 (Ki-1) [Ber-H2] Description The CD30 antigen, initially designated Ki-l, recognizes a single chain transmembrane glycoprotein that has been demonstrated to be homologous to members of the nerve growth factor receptor superfamily. The mature 120 kDa molecule is formed from 90 kDa precursor molecule processed in the Golgi system. The Ki-1 (CD30) antigen is expressed in mononuclear Hodgkins and multinucleated Reed-Sternberg cells in Hodgkins disease. It is expressed by the tumor cells of a majority of anaplastic large cell lymphomas, and by a varying proportion of activated T and B cells. CD30 is also expressed on embryonal carcinomas. The CD30 monoclonal antibody from the Ber-H2 cell line was included in the Fourth International Workshop on Human Leukocyte Differentiation Antigens. It distinguishes large cell lymphomas derived from activated lymphoid cells, from histiocytic malignancies and lymphomas derived from resting and precursor lymphoid cells, or from anaplastic carcinomas. CD30 and CD15 primary antibodies may be used in tandem to differentiate between anaplastic large cell lymphoma and Hodgkins disease (Reed-Sternberg cells). |
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| PHOTO DESC. | Cat No. | |
| Anaplastic large cell lymphoma stained with CD30 antibody. | intelliPATH FLX | IP 031 G10 |
| CONCENTRATE | N/A | |
| PREDILUTE | PM 031 AA, H | |
| CLONE | Ber-H2 | |
| DOWNLOADS | SOURCE | Mouse monoclonal |
| ISOTYPE | IgG1/kappa | |
| ANTIGEN | Ki-1 | |
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