Secretagogin
Secretagogin (SCGN) a hexa-EF-hand Ca (2+) binding protein, is found in prostatic adenocarcinomas as opposed to adenocarcinomas from other organs. Reports have demonstrated SCGN staining in most normal neuroendocrine tissues, except for the adrenal cortex. In other studies, SCGN staining was positive in 26 out of 31 small cell lung cancers, showing expression more frequently than neuron specific enolase (NSE), chromogranin or synaptophysin. Secretagogin has been demonstrated in a subset of brain tumors by immunohistochemistry. Studies using an affinity purified rabbit polyclonal antisecretagogin antibody and a murine monoclonal antibody revealed a neuron-specific cerebral expression pattern. SCGN was detected in singular neurons of the frontal and parietal neocortex, in basket and stellate cells of the cerebellar cortex, and in secretory neurons of the anterior part of the pituitary gland. SCGN is a novel neuroendocrine marker and should be useful in routine surgical pathology.
| Ordering Information |
Catalog Number |
Volume |
| Concentrate |
CP 389 |
AK, BK |
| Predilute |
PP 389 |
AA |
| intelliPATH™ |
N/A |
N/A |
| VP Echelon |
N/A |
N/A |
| A / AK = 0.1 ml |
B / BK = 0.5 ml |
C / CK = 1.0 ml |
G5 = 5.0 ml |
AA = 6.0 ml |
H / G25 = 25 ml |
L = 100 ml |
