MUC-4
MUC-4 (also called sialomucin complex) is a membrane-bound mucin that has been suggested to be implicated in malignant progression in humans and rats. The MUC-4 gene is expressed in various normal epithelial tissues of endodermic origin and carcinomas. In the respiratory tract, over-expression of the membrane mucin has been observed during malignant progression of mammary tumors in both humans and rats, suggesting that deregulation of MUC-4 might facilitate development of these malignancies. Studies have indicated that over-expression of MUC-4 results in suppression of both cell adhesion and immune killing of tumor cells. MUC-4 transcripts have been detected in normal respiratory epithelium and lung. Other studies have shown that MUC-4 is a very specific (100%) and sensitive (91.4%) marker of lung adenocarcinomas and is negative for mesotheliomas. MUC-4 expression in invasive ductal carcinoma of the pancreas is an independent factor for poor prognosis and predicts outcome in the patient.
| Ordering Information |
Catalog Number |
Volume |
| Concentrate |
CM 326 |
C |
| Predilute |
N/A |
N/A |
| intelliPATH™ |
N/A |
N/A |
| VP Echelon |
N/A |
N/A |
| A / AK = 0.1 ml |
B / BK = 0.5 ml |
C / CK = 1.0 ml |
G5 = 5.0 ml |
AA = 6.0 ml |
H / G25 = 25 ml |
L = 100 ml |
